Glyn Hodges' side will begin their campaign with an away game against Aston Villa on Monday 18th August, before hosting Derby County at Clayton Wood on Friday 29th August.
The majority of the home fixtures, however, will be played at Macclesfield Town's Moss Rose stadium after the Club agreed with the Conference side for them to play host to a number of matches.
The Potters are set to face Reading, Newcastle United, Wolverhampton Wanderers, Brighton & Hove Albion and Bolton Wanderers at the Cheshire venue.
Designated games at the Britannia Stadium this term are against Arsenal, West Bromwich Albion and Middlesbrough.
For a full list of the Under 21s' 2014/14 fixtures, click HERE.